Product Details

• Hardcover: 472 pages
• Publisher: Wiley-Blackwell; 1 edition (October 19, 2010)
• Language: English
• ISBN-10: 1405182733
• ISBN-13: 978-1405182737

Product Description

This comprehensive resource for fellows/trainees and candidates for recertification in gastroenterology summarizes the field in a modern, fresh format. Prominent experts from around the globe write on their areas of expertise, and each chapter follows a uniform structure. The focus is on key knowledge, with the most important clinical facts highlighted in boxes. Color illustrations reinforce the text.

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Product Details

• Hardcover: 424 pages
• Publisher: Wiley-Blackwell; Har/Psc edition (October 19, 2010)
• Language: English
• ISBN-10: 140518275X
• ISBN-13: 978-1405182751

Product Description

This comprehensive resource for fellows/trainees and candidates for recertification in gastroenterology summarizes the field in a modern, fresh format. Prominent experts from around the globe write on their areas of expertise, and each chapter follows a uniform structure. The focus is on key knowledge, with the most important clinical facts highlighted in boxes. Color illustrations reinforce the text.

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Product Details

• Hardcover: 544 pages
• Publisher: Wiley-Blackwell; 1 edition (October 19, 2010)
• Language: English
• ISBN-10: 1405182741
• ISBN-13: 978-1405182744

Product Description

This comprehensive resource for fellows/trainees and candidates for recertification in gastroenterology summarizes the field in a modern, fresh format. Prominent experts from around the globe write on their areas of expertise, and each chapter follows a uniform structure. The focus is on key knowledge, with the most important clinical facts highlighted in boxes. Color illustrations reinforce the text.

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Product Details

• Hardcover: 824 pages
• Publisher: BMJ Books; 3 edition (September 28, 2010)
• Language: English
• ISBN-10: 1405181931
• ISBN-13: 978-1405181938

Product Description

The only evidence-based  resource combining  gastroenterology and hepatology, this major textbook critically appraises the evidence for diagnosis, screening, and treatment of gastrointestinal and hepatic diseases, and provides clear recommendations for management.

A unique feature is the grading of both the evidence (randomized controlled trials, systematic reviews, or lower quality trials) and the treatment recommendations. This structure provides the reader with valuable guidance on implementation.

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Product Details

• Paperback: 752 pages
• Publisher: McGraw-Hill Professional; 1 edition (May 3, 2010)
• Language: English
• ISBN-10: 0071663339
• ISBN-13: 978-0071663335

Product Description

Featuring the chapters on Gastroenterology and Hepatology that appear in the landmark Harrison’s Principles of Internal Medicine, 17e, this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliability that has defined Harrison’s.

You’ll find coverage that reflects the expertise of renowned editors and contributors — presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, Harrison’s Gastroenterology and Hepatology is a must for students and clinicians alike.

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Product Details

• Hardcover: 368 pages
• Publisher: Springer; 1 edition (February 29, 2000)
• Language: English
• ISBN-10: 0792387554
• ISBN-13: 978-0792387558

Product Description

This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease’, which took place at the Royal Society of Medicine (RSM) in London, UK, on 29–30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.

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Product Details

• Hardcover: 192 pages
• Publisher: Springer; 1 edition (March 31, 2001)
• Language: English
• ISBN-10: 0792387708
• ISBN-13: 978-0792387701

Product Description

Univ. of Medicine and Pharmacy, Cluj-Napoca, Romania. Proceedings of the Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000. Discusses cholestatic liver diseases and gallstone disease. Extensive references.

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Product Details

• Hardcover: 384 pages
• Publisher: Springer-Verlag; 1 edition (September 2004)
• Language: English
• ISBN-10: 079238797X
• ISBN-13: 978-0792387978

Product Description

Portal hypertension is the most important complication of a great variety of both acute and chronic liver diseases. Nevertheless, hepatic cirrhosis is the most frequent cause of portal hypertension. Gastrointestinal bleeding due to rupture of oesophageal varices is, without doubt, the most severe complication of portal hypertension. At present, great advances are being made in the pathophysiology and in the development of new therapeutic tools for controlling and preventing this severe clinical event.

This book contains the papers presented and discussed during the Symposium on ‘Portal Hypertension in the 21st Century’, held in Montréal, Canada, in April 2004, and sponsored by Axcan Pharma Inc. and NicOx S.A. There are eight sections covering basic mechanisms, new drugs, prevention and current treatment of variceal bleeding, prevention of recurrent bleeding and hepatic hemodynamic monitoring.

An international faculty of authors have contributed chapters at an outstanding scientific level which will be vital reading for scientists and clinicians alike.

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Product Details

• Hardcover: 234 pages
• Publisher: Springer; 1 edition (August 3, 2004)
• Language: English
• ISBN-10: 0792387953
• ISBN-13: 978-0792387954

Product Description

This book is the proceedings of the Falk Symposium No. 138 on “State of the Art of Hepatology: Molecular and Cell Biology” (part of the XII International Falk Liver Week 2003 in honour of Hans Popper’s 100th birthday, held on October 20–11, 2003), and reflects the tremendous advances in the science of hepatology both at the molecular as well as the cellular level.

The book comprises four major sections. In Section I, the basic aspects of liver cell biology are covered, including RNA metabolism, regeneration, transport and metabolic functions, as well as fibrogenesis and malignant transformation. In Section II, the novel field of stem cell plasticity and cell therapy for liver diseases is discussed in detail, including stem cell biology, hepatocyte transdifferentiation from extrahepatic stem cells and their therapeutic use for liver cell repopulation, as well as hepatocyte transplantation. In Section III, novel therapeutic strategies for liver cirrhosis and hepatocellular carcinoma are presented, including the reversal of liver fibrosis, oncolytic biotherapy and different concepts of gene therapy for hepatocellular carcinoma. In Section IV, novel aspects of gene therapy and prevention of liver diseases are addressed, including small interfering RNAs, ribozymes, antisense oligonucleotides, as well as DNA vaccination.

An international faculty of outstanding scientists from different research areas presents the state of the art on these most important aspects of hepatology and their perspectives for future developments. Molecular and cell biology are at the very centre of research developments in modern hepatology and are of interest and importance to both basic scientists as well as clinicians involved in patient care.

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Product Details

• Hardcover: 320 pages
• Publisher: Academic Press; 1 edition (July 25, 2007)
• Language: English
• ISBN-10: 0123736056
• ISBN-13: 978-0123736055

Product Description

Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.

Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.

At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from “normal” “gastric” cardiac mucosa. In standard histology texts, this “normal gastric cardia” is 2-3 cm long.

In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity “reflux carditis”. In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient.

At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology.

The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients.

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Product Details

• Hardcover: 432 pages
• Publisher: Informa Healthcare; 1 edition (June 5, 2006)
• Language: English
• ISBN-10: 0824726413
• ISBN-13: 978-0824726416

Product Description

This reference supplies a comprehensive and current overview of every aspect of gastrointestinal microbiota. Expertly written chapters cover conventional and molecular techniques for the study of differing microbial populations, as well as the analysis of microbial activity and interaction with host bodies. Illustrative and up-to-date, this source showcases how fluctuations in our diet, environment, and pharmaceutical intake affect microbial composition and behavior.

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Product Details

• Hardcover: 168 pages
• Publisher: Informa Healthcare; 2 edition (August 25, 2004)
• Language: English
• ISBN-10: 1841843695
• ISBN-13: 978-1841843698

Product Description

Chronic hepatitis B and C affect 520 million people worldwide, and are a major cause of chronic liver disease and of mortality, despite the efficacy of the vaccine. Hepatitis B and C: Management and Treatment second edition provides a practical explanation of the natural history and management of the disease, and examines the benefits of the most recent drugs, and their effects, whether used in isolation or as part of a combination therapy. This second edition expands the coverage of treatment of various difficult-to-treat patients and will be a welcome guide to the physician in both clinical decision-making and in explaining the benefits and side-effects to the patient.

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Product Details

• Hardcover: 208 pages
• Publisher: Springer; 1 edition (October 31, 2003)
• Language: English
• ISBN-10: 0792387864
• ISBN-13: 978-0792387862

Product Description

Cell–cell and cell–matrix interactions are of fundamental importance for the development and the maintenance of tissues and organs in multicellular organisms. Adhesive processes are mediated and controlled by an increasingly large and complex number of cell adhesion molecules that are anchored to the cell surface membrane by transmembrane domains. According to their structural and functional features, cell adhesion molecules have been classified into at least four major families: the integrins, selectins, cadherins and members of the immunoglobulin superfamily. Apart from linking cells to each other or to components of the extracellular matrix, cell adhesion molecules function also as receptors that interact via their cytoplasmic domain with numerous signalling molecules including protein kinases and phosphatases, G-proteins, or proteins of the b-catenin/armadillo family. Cell adhesion molecules can activate various signalling pathways and as a consequence play a crucial role in the regulation of cell differentiation, proliferation, migration and apoptosis. During the last decade it has been recognized that acquired as well as inherited defects of cell adhesion molecules and adhesion-linked signalling molecules are the molecular basis of various types of disease including cancer, infectious and inflammatory disease, connective tissue disorders or blistering disease. This book is the proceedings of a Falk Workshop held in Berlin, Germany, on January 23–24, 2003, which brought together experts in different fields of research to stimulate the transfer of findings from basic research to clinical application. Section I focuses on cell adhesion molecules of the liver and their role in hepatocarcinogenesis and inflammatory liver disease. Section II deals with infection and fibrosis and with transforming growth factor b (TGF-b). Morphogenesis, cell migration and inflammation are the subject of Section III with a focus on the role of integrins in blood cell–endothelial interactions. In Section IV the importance of cell adhesion molecules for cancer and their role as potential target for cancer therapy will be discussed.

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Product Details

• Hardcover: 816 pages
• Publisher: Informa Healthcare; 2 edition (July 10, 2007)
• Language: English
• ISBN-10: 0849398967
• ISBN-13: 978-0849398964.

Product Description

Epidemiological studies have found that drugs are now the most common cause of liver failure in the United States, and the past decade has seen an explosion of new information concerning the immunology, toxicology, and pharmacology of drug-induced liver disease. This expertly written Second Edition supplies an in-depth discussion of the recent developments in drug-induced hepatotoxicity, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced liver disease.

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Product Details

• Hardcover: 96 pages
• Publisher: Springer; 1 edition (December 31, 2002)
• Language: English
• ISBN-10: 0792387821
• ISBN-13: 978-0792387824

Product Description

Universitat Frankfurt, Germany. Text is derived from the proceedings of the Falk Workshop held in Freiburg, Germany on June 2, 2002. Includes discussions about women of childbearing age and the issues surrounding pregnancy, autoimmune liver disease, and various treatment options.

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